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References Adams, T., Epa, V., Garrett, T., & Ward, C

J Exp Bot 62:869882 Price AH, Taylor A, Ripley SJ, Griffiths A, Trewavas AJ, Knight MR (1994) Oxidative signals in tobacco increase cytosolic calcium

The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)