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JANUMET is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2 [see Contraindications (4) and Warnings and Precautions (5.1)]

These side effects typically resolve without the need for medical intervention

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Reconstitute each vial separately, calculate dose based on that specific vials concentration, and never combine solutions

A 2014 review of studies indicated that berberine may help maintain healthy oxidative balance and inflammation in various tissues, including the liver, adipose tissue, kidneys, and pancreas

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