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Upon insertion into the skin, these nanoparticles selectively bind to specific biomarkers such as inflammatory cytokines (e.g., IL-6) present in ISF

subtilis mutant RB50:(pRF69)6o(Ade+), containing a transcriptionally-modified riboflavin operon with two SPO1-15 promoters, produced 13.014.0 g/L riboflavin in 48 h and 15 g/L in 56 h during cultivation in standard commercial batch and feed conditions (Table 1)

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