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Different species of -synuclein oligomers induce calcium influx and seeding

Advanced glycation, the creation of end products (AGEs), and the activation of protein kinase C (PKC) are some of the additional variables that may contribute to the development of hyperglycemia (26)

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The contribution of this mechanism to the overall glucose-lowering effect varies between different GLP-1 receptor agonists and tends to diminish over time with continued treatment