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The downstream effects include: Synaptogenesis : Formation of new synaptic connections in hippocampal neurons, driven by c-Met-mediated activation of PI3K/AKT and MAPK/ERK signaling cascades Spinogenesis : Growth of new dendritic spines, the structural substrate for excitatory synaptic transmission Neurotrophic support : In cell-based neurotrophic assays, Dihexa demonstrated potency approximately seven orders of magnitude greater than BDNF The HGF/c-Met pathway is distinct from the BDNF/TrkB and NGF/TrkA pathways targeted by most nootropic peptides

Refer to Table 3: Treatment of B 12 deficiency for supplementation routes, dosage and duration

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A Phase 1 open-label study evaluated the pharmacokinetics of oral cyanocobalamin formulated with SNAC compared to standard oral and IV B12 in healthy adults