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The experiments conformed to UK Home Office regulations under the Animals (Scientific Procedures) Act 1986, including Amendment Regulations 2012, and adhered to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines

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99% of Pacific Islanders have sufficient enzyme, Cytochrome P450 2D6 (CYP2D6), to metabolize kava, while from 79% to 88% of Caucasian populations have sufficient enzyme However, a study of 31 people in Hawaii who were regular kava drinkers showed a significantly greater elevation of two liver enzymes compared with people who were not kava drinkers

95% CI: 0.440.90 E-value for gout: 2.51, suggesting strong and robust relationship No difference was found significantly in risk of knee osteoarthritis HR: 1.05

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