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In glioma, numerous clinical studies collectively show that anti-angiogenic treatment can prolong progression-free survival but fails to improve overall survival [293]

Whilst it is impossible for investigators to consider all the factors at play within the package of whole diet, especially when comparing plant and animal derived proteins (Richter et al, 2015), studies consistently report that achieving adequate folate (vitamin B9) status is an important factor to mitigate the risk of homocysteine accumulation (Selhub et al, 2000

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