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First, there must be a clear scientific rationale: why this target, why this compound, and why it could potentially benefit that type of patients

this is the widest part of the curve

Synthesis process GSH biosynthesis follows a typical two-step, ATP-dependent enzymatic reaction

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Attaching of N -Boc-norleucine, removal of Boc, acetylation of norleucine amino group with acetic anhydride, HF mediated cleavage of the resulting peptide from the polymer support, and finally purification using RP-HPLC afforded the target compound 2 in 5560% overall yield [18,24]