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MOTS-c MOTS-c is a mitochondrial-derived peptide that influences metabolic regulation and energy utilization

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B12 deficiency can result from dietary factors such as a lack of animal products or from conditions affecting absorption like pernicious anaemia or gastrointestinal surgery

The NIH factsheet explains that no tolerable upper intake level has been set for B12, because it has a low potential for toxicity in healthy people

Unfortunately, many people living with obesity cannot lose weight over the long term with lifestyle changes (diet and physical activity) alone [3]

For context, about 60% of CagriSema participants hit the 20% weight-loss mark, and nearly 1 in 4 lost 30% or more