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The association of IGF-1 and IGF-1R apparently leads to changes in metabolism, prevention of cell death (apoptosis), promotion of cell growth (hypertrophy), differentiation and cell division (hyperplasia), normal development, and even malignant growth

while glycan from LBD Asn 402 is oriented towards ATD and might interact with its lower lobe (Fig

Melanin Reduction Glutathione causes the production of melanin (skin pigment) to change from darker eumelanin to lighter pheomelanin, which results in more even skin tone, reduced pigmentation, and brighter skin

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The off-period prevents receptor downregulation and maintains responsiveness