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Targeted pathways Sirtuin/NAD+ activation and GSH antioxidant defense two complementary pillars of mitochondrial health

16 , e1008566 (2020)

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A mediation analysis of the SUSTAIN 15 trials showed minor contribution of nausea/vomiting to the greater weight reduction during the therapy with once-weekly semaglutide versus its comparators

Notably, even though we included all the literature addressing the effects of ES and nutritional interventions in both males and females, the included studies mostly failed to test whether the efficacy of the nutritional supplementation might be sex-specific