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Table 1 shows the main factors considered to have a deleterious effect on the intestinal barrier status: microplastic [20,21,22,23,24,25], nanoparticles [26,27,28,29], detergents and emulsifiers [30,31,32,33,34,35,36], the state of the intestinal microbiota [37,38,39,40,41,42,43,44,45] and diet [46,47,48,49,50,51]

This study is registered to ClinicalTrial.gov (N NCT03295760)

Therefore, further studies are required to determine their clinical efficacy

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