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However, female C57BL/6J mice are relatively resistant to diet-induced weight gain, limiting their utility for weight loss studies in females (18, 19)

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In these advanced stages, cardiovascular mortalityprimarily due to atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and arrhythmiasaccounts for approximately 40% to 50% of deaths [5]

And expect advantages beyond increased GLP-1 levels

The consistency of the preclinical data across multiple studies and laboratories supports the mechanistic hypothesis