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The mechanism is not where the clinically meaningful differences live

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M., Bruzas, M

In contrast, the mutations significantly reduced the receptor activity when EX4-fused ECD was expressed separately from the TMD, especially for the Q211A/H212A/Q213A, E373A/H374A/A375 and V370A/M371A/D372A mutations, which nearly abolished the receptor activity (Figure 8a and e, expression levels shown in Supplementary Figure S2B and D and the normalized activity shown in Supplementary Figure S3A and C)