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While existing models continue to guide mechanistic research and therapeutic testing, further development of models that more closely align with human pathophysiology is crucial to improve translational validity (295, 303, 304)

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The degree of activation and fatigue plays a crucial role in defining the body's immune responses against tumors and the effectiveness of immunotherapy

Over time, this process creates lesions, scars that interrupt communication along the central nervous system and produce symptoms ranging from numbness and fatigue to vision loss and difficulty walking