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108 Overall, these studies suggest that although weight loss from dietary restriction can compromise skeletal health, incorporating exerciseparticularly endurance trainingcan preserve BMD and hormonal factors, and reduce bone resorption, thereby offering partial protection to the skeleton during obesity treatment

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Loose, sagging skin following rapid fat reduction can undermine the psychological benefits of transformation

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In the STEP trials, semaglutide produced average weight loss of 1518% at the 2.4 mg maintenance dose, with approximately 80% of participants achieving clinically significant (5%) weight loss