Carcinogenesis 27, 107480
This has even been achieved in lower eukaryotes such as Saccharomyces cerevisiae , where a significant resistance to chlorambucil and doxorubicin (eight- and 16-fold, respectively) was reported in cells transfected with mammalian GST isozymes (Black et al ., 1990)
This inherent stability, combined with its lack of a known toxicity profile in preclinical studies, made it a prime candidate for further exploration
Abstract Rational assembly of small molecule libraries for purposes of drug discovery requires an efficient approach in which the synthesis of bioactive compounds is enabled so that numerous structurally related compounds of a similar basic formulation can be derived
Consequently, miR-181b diminishes CXC motif chemokine ligand 1,2 (CXCL1) and (CXCL-2) via interacting with their 3 untranslated region (3 UTR)
[PubMed: 32741481] 30