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"Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial." December 11, 2025

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did not directly point out the treatment potential of GLP-1R agonists for DPN, these results may support the peripheral neuroprotective effect of GLP-1R agonists considering the close association of DPN with adverse limb events (60)