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Once applied, the patch uses a combination of permeation enhancers and micro-needles (depending on the technology) to deliver the medication through the outer layers of skin

They promote small, dense LDL particles (the most atherogenic type), increase inflammation in blood vessels, contribute to arterial plaque formation, and are strongly associated with metabolic syndrome

doi: 10.1016/j.jmb.2019.02.004 103 HeL.LiangJ.ChenC.ChenJ.ShenY.SunS.et al

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When people lose weight, especially a significant amount, it can cause temporary changes in hormone levels, which may, in turn, affect the menstrual cycle