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DECLARE-TIMI 58 Trial The DECLARE-TIMI 58 trial outcomes (composite risk of CV disease and hospitalization for heart failure and its components, including CV and renal events) were analyzed according to baseline BMI categories (normal to very obese) [31]

Mass Spectrometry Applications Mass spectrometry enables: N-terminal truncation identification C-terminal truncation analysis Relative impurity quantification Structural confirmation of shortened variants Why Truncation Monitoring Matters These variants can potentially affect: Product potency Stability Pharmacokinetics Regulatory comparability assessments As a result, truncation products must be carefully monitored throughout biosimilar development