Quick Answer: Tirzepatide does not cause high blood pressure and typically reduces both systolic and diastolic blood pressure by 2-8 mmHg through weight loss and improved metabolic function
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This is not surprising, considering that tirzepatide and semaglutide evoked more pronounced TBWL and also have glucose-lowering effects by slowing gastric emptying, stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner, independent of their effects on body weight 50,51
Some healthcare providers consider this combination for patients who have hit a weight loss plateau on a GLP-1 medication alone
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With each dose, symptoms are briefly covered, only to reemerge when the medication wears off, reinforcing cycles of dependence, instability, and patient frustration