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Hou Y, Ernst SA, Heidenreich K, and Williams JA

However, using an ECD-binding antibody Fab fragment (Fab7F38) for co-crystallization, we successfully crystallized the GLP-1RPF-06372222Fab7F38 complex

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Large clinical trials have not identified increased fracture risk with these treatments

Studies tracking patients 12 years post-discontinuation show net weight loss of 48% compared to baseline, suggesting that behavioral changes during treatment (improved food choices, smaller portion awareness) persist in some degree

doi: 10.1016/0026-0495(87)90153-3 58 NauckMAHeimesaatMMOrskovCHolstJJEbertRCreutzfeldtW