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Taken together, these discrepant findings likely reflect differences in tumor model, target cell compartment, glycemic context and exposure conditions, indicating that the effects of GCG in CRC are context-dependent

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But the annual cost of these drugs in the US upwards of $11,000 at recent list prices, though net prices may be lower with rebates negotiated by pharmacy benefit managers has raised concerns about the fiscal impact of broad coverage of GLP-1 drugs on Medicare, other health insurers, and patients

The study authors concluded that effects were greater at doses at or over 3 grams daily