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This includes employing mitochondrial-targeted peptides and exploring gene therapies aimed at correcting defective mitophagy (e.g., via the PINK1-Parkin pathway) or normalizing imbalanced mitochondrial dynamics (Wang et al., 2025a

Diarrhea specifically affected 9% to 20% of participants across dose groups in Phase 2

No clinical data supports any administration regimen, schedule, or combination with other compounds

645 The levels of ROS and MDA in spinal cord of mice suffering from bone cancer pain increase, while those of SOD decrease, accompanied by mitochondrial ultrastructural changes

The half-life is short, roughly 10 to 12 minutes

Daniel Drucker joined the Habener laboratory in 1984