Allow at least 4 to 6 weeks at a stable retatrutide dose before drawing conclusions about your cardiovascular response
Keep in mind that some of these contain caffeine or other stimulants, so youll want to make sure that you dont overdo it on top of the caffeine you may already be having in your day
Call 999 or go to your nearest A&E immediately if you experience: Signs of a severe allergic reaction (anaphylaxis), including swelling of the face, lips, tongue, or throat, difficulty breathing, or a widespread rash with collapse Seek urgent medical advice if you experience: Severe or persistent vomiting that prevents you from keeping fluids down Signs of dehydration, including dizziness, dark urine, or significantly reduced urination Severe abdominal pain, particularly if it radiates to the back this may indicate pancreatitis, a rare but serious adverse effect associated with GLP-1 receptor agonists [11] [12] Pain in the upper right abdomen, fever, yellowing of the skin or eyes (jaundice), pale stools, or dark urine these may be signs of a gallbladder problem, such as gallstones or cholecystitis, which have been associated with this class of medicine and with rapid weight loss Symptoms of hypoglycaemia (low blood sugar), such as shakiness, sweating, confusion, or palpitations the risk is higher if you are also taking insulin or a sulfonylurea
Phase 3 data will be required before any firm conclusions can be drawn
If GI side effects persist beyond the adjustment period or are severe enough to significantly impact quality of life, dose adjustment may be warranted
JAMA Oncology
