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The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)

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Common variants include: GSTM1 null : 40-50% of population-reduced capacity to neutralize environmental toxins GSTP1 variants : Impaired detoxification of carcinogens 6

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