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Curcumin analog ALZ003 can induce ubiquitination degradation of androgen receptor and significantly increase the sensitivity of GBM cells to temozolomide both in vitro and in vivo, and the mechanism may be related to ROS accumulation, lipid peroxidation and inhibition of GPX4, which are major features of ferroptosis

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Lastly, the potential beneficial effects GSH and other antioxidants in ITZ-associated hepatotoxicity should be confirmed in clinical trials

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A 2007 study of sixteen healthy elderly volunteers found that five hundred milligrams of one particular ampakine unequivocally improved short-term memory, though it appeared to detract from episodic memorythe recall of past events