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In 2025 was published randomized, sham-controlled trial (mPNS + conventional medical management [CMM] versus sham + CMM) reported superior pain relief

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Erythritol and Xylitol Effects: Both erythritol and xylitol can stimulate GLP-1 release from intestinal L-cells

Such results are about double what older weight-loss drugs achieve, according to a 2021 article published in the New England Journal of Medicine

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