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Further, we carried out electrophysiological assays measuring key gating properties like rates of desensitization, recovery from desensitized state and EC 50 values for agonist glutamate

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showed that PIEZO-mediated mechanosensation triggers KCNN4-dependent potassium efflux, leading to NLRP3 inflammasome activation and subsequential pyroptosis [57]

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This compression of the dosing interval can lead to higher peak levels and unpredictable side effects

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