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Much of Noopept cognitive effect may be mediated through its metabolite cycloprolylglycine (cPG), which concentrates preferentially in the hippocampus and has been shown to reduce hippocampal cell death, increase BDNF mRNA, and modulate inflammatory cytokine expression

Additional peptides with mood-relevant mechanisms Beyond the primary peptides discussed above, several additional compounds demonstrate mechanisms relevant to mental health, though their evidence bases for mood disorders specifically are less developed