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Systemic regulation of iron metabolism primarily occurs in the liver, where hepcidin binds to FPN, leading to its degradation and inhibition of iron export, thereby contributing to intracellular iron accumulation [99]

doi: 10.1152/ajpgi.00304.2014 162 Tosello-TrampontA-CLandesSGNguyenVNovobrantsevaTIHahnYS

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