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Vahldieck C, Cianflone E, Fels B, Lning S, Depelmann P, Sabatino J, Salerno N, Karsten CM, Torella D, Weil J, Sun D, Goligorsky MS, Kusche-Vihrog K

It is speculated that TMAO may aggravate the formation of atherosclerotic plaque by activating the PERK pathway and activating ERS

this hypothesis is also given credence by the common finding of GSTP overexpression in tumor cell lines that are not drug resistant

Similarly, another in vitro study found that TMAO can also upregulate the NF-B signaling pathway to promote adipogenic differentiation and inhibit the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) (59)

Mingin, G

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