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Metformin and certain reflux medications can lower your bodys ability to absorb B12 from oral supplements

Unlike oral supplements, which must pass through the digestive system and may not be well absorbed, injections deliver the vitamin directly into the bloodstream, allowing for quicker and more efficient absorption

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Efficacy is unaffected once the peptide reaches the bloodstream it sits in the bodys own roughly 150 mM saline regardless of what you mixed it with. NAD+ is different: its pain is acidity, not mast cells reconstituted NAD+ sits near pH 3.5

This happens by inhibition of vit D3 which is responsible for calcium absorption.

However, if you have a severe deficiency or a condition that prevents proper B12 absorption, injections may be the better choice