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Skin tone may gradually return to its natural baseline if maintenance treatments are discontinued

Cell Physiol Biochem 39(6):2297307 Long F, Dong C, Jiang K, Xu Y, Chi X, Sun D et al (2017) Melatonin enhances the anti-tumor effect of sorafenib via AKT/p27-mediated cell cycle arrest in hepatocarcinoma cell lines

Early Alzheimer's disease pathology in human cortex involves transient cell states

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Specifically, the combination significantly reduced TGF--induced ROS generation in HSCs and attenuated the nuclear translocation of SMAD2/3, key mediators of pro-fibrogenic and inflammatory signaling

A better understanding of dose-response relationships is needed to optimize therapy