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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Bravo-San Pedro JM, Kroemer G, Galluzzi L
Excipient studies on lyophilized rhGH show that sugar and polyol stabilizers (mannitol, sucrose, trehalose) protect the protein's secondary structure and limit aggregation in the dry state by satisfying water-binding sites and stabilizing the amorphous matrix around the protein (Costantino et al., 1998)
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