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The Bottom Line: Veterinary cardiologists who prescribe pimobendan to MVD-affected dogs in Stage B1 are risking their patients' lives in order to perform undisclosed clinical experiments

KEAP1-dependent NRF2 activators Electrophilic compounds The most known NRF2 activators are electrophiles electron-deficient species able to form covalent bonds with electron-rich nucleophiles through a variety of chemical pathways which can covalently bind and modify cysteine residues in KEAP1 [273, 274]

However, Novo outperforms Lilly on access to basic services