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In the state of brain insulin resistance, insulin signaling pathways such as the PI3K/Akt pathway become abnormal, and abnormalities in insulin signaling pathways lead to a decrease in A clearance, which promotes A deposition (Zheng and Wang, 2021)

Ongoing proliferative signaling, in particular upregulation of receptors, ligands, or circumvention by feedback mechanisms, is a major tumor cell characteristic (32)