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If your total energy intake is low, your body prioritises using that energy for brain and vital organ functions, like your heart pumping blood around your body and your kidneys filtering waste and forming urine, as opposed to maintaining or building muscle

It's a sustainable reduction in calories with the body's appetite regulation system working in your favor

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For example, a 2010 study demonstrated that central administration of pan-melanocortin agonist MT-II decreased food intake in WT, Mc3r KO, and Mc4r KO mice ( Previous melanocortin agonist clinical candidates (20042022) In the early 2000s, several MC agonists were developed and trialed as weight management therapies