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The in-vitro cell line studies and in-vivo animal experiment results demonstrated that the DTIC@CMSN showed remarkable tumor suppression and increased lifespan/ survival due to targeted tumor killing compared to free DTIC after combining with the aPD1 immunotherapy

Razavi R, Kenari RE

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For example, specialized enteroendocrine K- and I-cells secreted glucose-dependent insulinotropic peptide (GIP) and cholecystokinin (CCK), whereas enteroendocrine L-cells produce preproglucagon-derived peptides [GLP-1, glucagonlike peptide-2 (GLP-2), and oxyntomodulin] and also peptide YY (PYY) (10)