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In vitro pull-down assay showed that GSTP-S184D displayed a stronger affinity to bind HMGB1 than GSTP (WT), but GSTP-S184A did not combine with HMGB1, indicating that Ser184 phosphorylation was necessary for the association between GSTP and HMGB1 (Figures 5H,I)

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An analysis of data from 596 PsA patients in the British Society for Rheumatology Biologics Register (BSRBR) found that the safety profile with these agents was not substantially different from that with nonbiologic DMARDs, and that the safety in PsA patients was similar to that seen in serologically negative RA patients

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