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This phenomenon might be attributed to the BH4-mediated conversion of phenylalanine to tyrosine, a process crucial for the production of 4-OH benzoate, a precursor in CoQ10 biosynthesis

N Engl J Med 2021;385:1451-61

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Collectively, these data show that DMF constitutes an attractive compound for the pharmaceutical industry for drug repurposing in other neurodegenerative diseases ( TABLE 1 DMFs ability to alleviate pathological hallmarks of AD, PD and ALS in pre-clinical models in the context of Nrf2 activation

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