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Second, proteolytic enzymes throughout the gastrointestinal tract, including pepsin in the stomach, trypsin and chymotrypsin in the small intestine, and brush-border peptidases, cleave peptides into inactive fragments

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All methods were reported in accordance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines ( ensuring transparent and comprehensive reporting of experimental design, animal husbandry, experimental procedures, sample size, statistical methods, and ethical considerations

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Decreased exercise tolerance during treatment was linked with greater lean body mass loss in both groups, but to a greater extent in tirzepatide-treated patients

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