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SAMe depletion in AD animal models and in vitro has been shown to perturb DNA methylation with resultant increases in the expression of Amyloid Beta Precursor Protein (APP), Presenilin-1 (PS1) and Beta-Secretase 1 (BACE1) genes, stimulating A production and neurodegeneration (1316)

If symptoms persist beyond 8 weeks at a stable dose, clinical evaluation is important to exclude other causes (infection, dietary intolerance, concurrent medications)

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With regards to the body, everything is connected