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This unique sex difference was subsequently confirmed in two follow-up studies, though with more modest reported improvements in female lifespan 7,8 , while a life shortening effect was observed in males 8

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Using the available research as a reference, the recommended starting dose of semaglutide is 0.25mg/weekly, and it should be increased every four weeks up to a maximum of 2.4mg/weekly [25, 26]