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Cecal mass did not significantly differ between groups (Supplementary Table S2)

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Despite the lack of extra support for lifestyle modification as part of the SURPASS program, 4069% of patients achieved 10% weight loss with the highest doses of tirzepatide (1015 mg), which ranged from 9.5 kg to 12.9 kg [100]

Its much faster and more effective than taking an oral supplement, as that must pass through the digestive system (which reduces absorption)

Replacement of GLP-2R ECL1 by poly-alanine abolished the ability of GLP-2 to elicit cAMP response, while replacement by that of GLP-1R diminished its potency by 196-fold