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ALCL anaplastic large cell lymphoma, ALK anaplastic lymphoma kinase, AXL tyrosine-protein kinase receptor UFO, c-MET hepatocyte growth factor receptor, EMA European Medicines Agency, FDA US Food and Drug Administration, FLT-3 fms like tyrosine kinase 3, KIT KIT proto-oncogene receptor tyrosine kinase, MTC medullary thyroid cancer, NSCLC non-small cell lung cancer, RCC renal cell carcinoma, RET REarranged during Transfection, ROS1 ROS proto-oncogene 1, TIE-2 tyrosine-protein kinase receptor TIE-2, TKI tyrosine kinase inhibitor, TRKB tyrosine receptor kinase B, VEGF vascular endothelial growth factor, VEGFR vascular endothelial growth factor receptor a ALK -fusion positive and ROS1 -positive NSCLC as detected by an FDA-approved test In this review, we will present an overview of approved and novel promising c-MET-inhibitors, with a focus on their safety profile and tolerability

10.1136/jnnp-2019-322588 J

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Amino Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe Molecular Formula: C78H123N23O23S2 Molecular Weight: 1815.1 g/mol CAS #: 221231-10-3 InChI: 1S/C78H123N23O23S2/c1-9-41 Proper storage ensures AOD 9604 peptide stability for research applications: Lyophilized Form: Reconstituted Form: Handle peptides in clean laboratory environments using sterile techniques