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Systemic IR is widely-reported to co-incide with macrophage accumulation and activation inside adipose (62), however, adipose IR can manifest adipose macrophage accumulation and activation (63), suggesting that, at least in some instances, IR can precede an inflammatory state and may in fact represent a danger signal causing the eventual activation of Kupffer cells and liver macrophages

Kinetic and structural analyses of hepatitis C virus polyprotein processing

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