However, with direct injection, if you do not need the additional B12, it may result in high levels in your blood that can cause side effects including gastrointestinal issues, headache and dizziness, tiredness and weakness, or skin irritation until the excess is flushed out via your kidneys and urine
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Those who don't produce enough intrinsic factor can become deficient
The 60-80% absorption rate means more peptide reaches systemic circulation, potentially requiring lower total doses despite higher upfront costs
That yields 2.5 mg/mL, which means 0.1 mL on a 1 mL insulin syringe (10 units on a U-100 scale) delivers 250 mcg
Cochrane Database of Systematic Reviews 2005, Issue 3