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67,68,69 Recently, a P495T variant of the GHR that is associated with increased incidence of lung cancer in various ethnic groups was shown to prolong GH signaling, which leads to increased expression of genes associated with tumor proliferation and epithelial-to-mesenchymal transition

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Six Biophysical screening methods miss a large proportion of crystallographically discovered fragment hits: a case study

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Because levels are often quite low before a deficiency is recognized, it can take some time for serum concentrations to even out and symptoms to subside