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At the same time, ellagic acid also prevented the decrease of the mitochondrial membrane potential ( Yet another phenolic acid, rosmarinic acid, has been found to reduce the amount of reactive oxygen species and malondialdehyde, which in turn attenuates cellular oxidative stress and protects hydrogen peroxide-treated glial cells (Lee et al., 2008) on SH-SY5Y (human dopaminergic neuron cells) by controlling the upregulation of Bax and the downregulation of Bcl-2, and reduce mitochondrial membrane potential by reducing reactive oxygen species
While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration
Chemical identity: Gly-His-Lys-Cu(II)
In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphidebond formation and consider its role in protecting the cell from endoplasmicreticulumgenerated oxidative stress
